objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

objective(s): occlusal trauma is one of the most common forms of oral biting dysfunction. long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (cntf) on injured masseter muscle. materials and methods: male wistar rats (n=36) were randoml...

background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...

background and purpose: brain-derived neurotrophic factor (bdnf) is present in the hippocampus and cerebral cortex in high concentrations and has an important role in development, maintenance and regeneration of the nervous system. the aim of this study was to produce active bdnf in e.coli using transforming plasmid. methods: to construct an expression plasmid of bdnf, a gene coding for it was ...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

background exposure to morphine decreases neurogenesis in the hippocampus. recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. objectives this study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be re...

post-traumatic stress disorder (ptsd) is a syndrome causing from a severe traumatic happening that leads to threatened death or injury. ptsd is associated with changes in limbic, hippocampal, and prefrontal cortical region function due to changes in synaptogenesis, dendritic modifying, and neurogenesis. changes in neuron in ptsd patients result from pathophysiological disturbances in inflammato...

objective(s): the present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. materials and methods: oxaliplatin (5 mg/kg) or saline was administered to adult male sprague-dawley rats.  gabapentin (60 mg/kg, ip) or vehicle was injected daily. mechanical allodynia was assessed us...